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Clinical CardiogeneticsFrom Springer
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Clinical management and signs�are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic.
The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner.
The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately.
Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included.
This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as:
Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?
- Sales Rank: #4599347 in Books
- Published on: 2011-03-10
- Original language: English
- Number of items: 1
- Dimensions: 10.50" h x 8.00" w x .75" l, 2.85 pounds
- Binding: Hardcover
- 455 pages
From the Back Cover
Clinics for cardiogenetic disorders have been established in many academic teaching hospitals in Europe. In these clinics, cardiologists, clinical and molecular geneticists, genetic nurses, and social workers closely cooperate to provide optimal care for individuals with cardiac disease of probable genetic origin and their family members. However, the prevalence of genetic cardiomyopathies and primary electrical heart diseases is sufficiently high, that it is neither desirable nor possible that the care for this group of patients and their relatives remains solely restricted to a small number of academic centers. Therefore basic knowledge on the genetic aspects of these types of disorders and on what to do with as yet asymptomatic at-risk family members should be considered to be a prerequisite for all practising cardiologists. Many cardiologists have not been specifically trained in genetics, let alone in explaining genetics to their patients. Clinical Cardiogenetics compiles the massive amount of information available in a single easy to read textbook. It does not require prior expert genetic knowledge and provides a practical clinical primer for cardiologists and other physicians involved in the management of these patients. With the continuing increase in genetic knowledge, and the expanding possibilities to prevent fatal arrhythmias in those individuals at high risk, a steady increase in questions regarding genetics from patients and their relatives in the years to come should be expected. This comprehensive textbook is a valuable tool in dealing with such questions.
Most helpful customer reviews
0 of 0 people found the following review helpful.
I would recommend that a copy of this book be on hand for any medium to large cardiology group.
By J. D. Christensen
There are now a number of cardiology guidelines referencing genetic testing for a wide variety of syndromes ranging from the familial thoracic aneurysm syndromes, cardiomyopathies and arrhythmias to adults with congenital heart disease. For most of us who graduated more than a decade ago, the realms of genetic testing and family counseling is a highly unfamiliar territory.
This outstanding, well-illustrated and well-referenced book discusses the current state of the art in a clear and well-organized way.
The book begins with a well written review of basic genetics and molecular biology -necessary for those of us who are far from the classroom stage of our careers.
Following that are clear chapters regarding specific disease entities (Congenital heart disease, muscular dystrophy, hypertrophic cardiomyopathies, arrhythmias, connective tissue disorders etc). The chapter on Noncompaction cardiomyopathy is the most complete thing I've found on this entity to date.
The book also has chapters which turn the picture around to specific clinical finding and work backwards to the syndromes that should be considered (i.e. "Sudden Cardiac Death in the Young"). It is not just a book of zebras; plenty of horses are reviewed as well (The pharmacogenetics of Atherosclerosis, Genetics of arterial thrombosis, The genetics of AAA).
I would recommend that a copy of this book be on hand for any medium to large cardiology group. It works well both as a reference for occasional user and as a read-through book for the cardiologist with a deeper interest/ Clinical Cardiogenetics
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